GSK2807 Trifluoroacetate

CAS No. 2245255-66-5

GSK2807 Trifluoroacetate ( —— )

Catalog No. M22934 CAS No. 2245255-66-5

GSK2807 Trifluoroacetate is a selective and SAM-competitive inhibitor of SMYD3 (Ki: 14 nM; IC50: 130 nM).GSK2807, a potent and selective, SAM-competitive inhibitor of SMYD3 (Ki = 14 nM).?A high-resolution crystal structure reveals that GSK2807 bridges the gap between the SAM-binding pocket and the substrate lysine tunnel of SMYD3.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 177 In Stock
10MG 260 In Stock
25MG 439 In Stock
100MG Get Quote In Stock
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Biological Information

  • Product Name
    GSK2807 Trifluoroacetate
  • Note
    Research use only, not for human use.
  • Brief Description
    GSK2807 Trifluoroacetate is a selective and SAM-competitive inhibitor of SMYD3 (Ki: 14 nM; IC50: 130 nM).GSK2807, a potent and selective, SAM-competitive inhibitor of SMYD3 (Ki = 14 nM).?A high-resolution crystal structure reveals that GSK2807 bridges the gap between the SAM-binding pocket and the substrate lysine tunnel of SMYD3.
  • Description
    GSK2807 Trifluoroacetate is a selective and SAM-competitive inhibitor of SMYD3 (Ki: 14 nM; IC50: 130 nM).GSK2807, a potent and selective, SAM-competitive inhibitor of SMYD3 (Ki = 14 nM).?A high-resolution crystal structure reveals that GSK2807 bridges the gap between the SAM-binding pocket and the substrate lysine tunnel of SMYD3. GSK2807 is 24-fold selective for SMYD3 in comparison with the closely related enzyme SMYD2 (Ki=14±6 nM and 345±36 nM, respectively).
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    SMYD3
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2245255-66-5
  • Formula Weight
    566.53
  • Molecular Formula
    C21H33F3N8O7
  • Purity
    >98% (HPLC)
  • Solubility
    H2O:50 mg/mL (88.26 mM)
  • SMILES
    NC1=C2C(N([C@H]3[C@H](O)[C@H](O)[C@@H](CN(CC[C@H](N)C(O)=O)CCCN(C)C)O3)C=N2)=NC=N1.OC(C(F)(F)F)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Van Aller GS, et al. Structure-Based Design of a Novel SMYD3 Inhibitor that Bridges the SAM-and MEKK2-Binding Pockets. Structure. 2016 May 3;24(5):774-781.
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